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Amoxycilline-polyethylene Glycol (PEG) 4000-tween 80 Solid Dispersion : Bactericide Effect Against Staphylococcus aureus and the Usage in the Direct Compression (Campuran Padat Amoksisilin-polietilen Glikol (PEG) 4000-tween 80 : Daya Hambat terhadap Staphyloccus aureus dan Penggunaannya dalam Tablet Cetak Langsung)

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The study of the interaction between amoxycilline and polyethylene glycol (PEG) tween 80 (PT) solid dispersion had been carried out using the differential scanning calorymetrics (DSC) and infrared spectrophotometric methods. The bactericide effects of the selective solid dispersion, then, were observed using the diffusion methods, and the other certain compositions were undergone to the direct compression formulation. The results showed the different profile of the DSC thermogram in accordance with the drug mole fractions, while the infrared spectra of the selective solid dispersions showed the shift and the change of the peak profiles of the functional groups. These are the evidences of the van der Waals and hydrogen band interactions. The bactericide effects data, mean while, indicated that the lower mole fraction solid dispersions gave the more effective action, that means, FT contributed in the membrane permeabolity modification. Data of the direct compression trials (PT as a filler) gave the better physical properties of the direct compression pre-powder, however the tablet disintegration time were longer and the dissolution rates were lower ones. These data indicated the different process occured in the dissolution/releasing mechanism of the active substance, and the sequence investigation are necessary.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Majalah Farmasi Indonesia,7(2)1996:87-99

Penerbit

: ., 1996

Deskripsi Fisik

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Bahasa

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

amoxicillin
staphylococcus aureus

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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