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Interactions of the Immunocompetent Cells in Bronchial Asthma (Interaksi Sel-sel Imunokompeten pada Asma Bronkiale)

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The presence of immunocompetent of bronchial asthma in hypersitive individuals. The cells comprise various populations, such as mat cells, basophils, neutrophils, macrophages, dentritic cells and lymphocytes, in which the T--cells are believed to play a centralrole. It has been demonstrated than CD4 T-cells consist of CD45RO reactive population and CD45RA, each secreting different cytokines. In terms of cytokine pattern production, these T-cell subpopulations are similar, to those found in the murine system, i.e. TH1 and TH2 cells. The CD45RO+IL-4 and IL-2 cells produce directly or indirectly that govern the proliferation and differentiation of B-cells to IgE-secreting plasma cells, by which IgE antibodies are responsible for development of allergic type I reaction. In addition, the number of T-cells expressing activation markers, like IL-2R, VLA-1 and HLA-DR increases in the serum of asthmatic patients, as well as in their bronchoalveolar lavage and bronchial biopsies. Moreover, the CD4+ T-cells produce IL-3, GM-CSF, IL-4, IL-5, IL-6 and IL-10 that induce mast cell differentiation and activation and recruitment of eosinophils. The function of dendritic cells and macrophages in antigen presentation to either naive or activated T-cells should be noted. Finally, immunologic-based therapy for the airways hyperreactivity may be proposed. This concept includes the regulation of certain cytokine production governing TH1 subpopulations, and by eliciting an optimal mucosal IgA response to down-regulate the production of IgE antibodies.

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Berkala Ilmu Kedokteran,27(4)1995:212-218

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: ., 1995

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asthma

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