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Metastasis Mechanism to the Bone (Mekanisme Terjadinya Metastasis ke Tulang)

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During the progression stage, malignant tumors showed heterogenecity with some cells showing invasive and metastatic capabilities. Bone metastasis is usually hematogenic and predominantly in red bone marrow. This is supported by retrograde vein flow (Botson's plexus), micro-anatomy of the vascularized channels in red bone marrow in sinusoid system, high blood flow and higher concentration of cytokines in bone marrow than in other tissues. Bone matrix resorption is not directly by tumor cells itself but through asteoclast asteolysis. Tumor cells produces local or humoral osteoclast activating factors resulting hypercalacaemia and pathologic fracture due to osteoclastic process. Metastatic processes is always accompanied by angiogenesis so that tumor cells could proliferate in the new circumtances. The most frequent malignant tumor metastasing to bone is carcinoma.

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Jurnal Kedokteran Yarsi,3(1)1995:93-101

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: ., 1995

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bone neoplasms
neoplasms metastasis

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