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Pharmacokinetics Profile of Suramin in Trypanosomal Infected Rat (Profil Farmakokinetik Suramin pada Tikus Terinfeksi Tripanosomiasis)

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The influence of tripanosomal infection on pharmacokinetics profile was investigated after intravenous threrapeutic dose (10 mg/kg. body weight) administration of suramin to 12 male PERUM BIOFARMA Wistar rat. The method of analysis of the plasma drug concentration was the iron paring reverse phase High Performance liquid Chromotography and 2 naphtol as an internal standard. The result shows that the distribution and elimination of half-time were 9.94-24.9 hours and 61.37-178.1 hours respectively, area under the curve was 848.5-1850.5 ug. houres/ml, the mean of drug residing time in blood was 81.8-188.2 hours, volume distribution steady state was 173.4-491.2 ml/kg, and clearance was 1.30-2.91 ml/hour/kg. It can be concluded that the quality of plasma-bumin influences considerably the kinetics of the suramin profile in trypanosomal infected rat.

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Jurnal Kedokteran Yarsi,3(1)1995:39-45

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: ., 1995

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suramin
trypanosomiasis

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