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The Effect of Ketamine on Ventilation : A Study of Three Premedication Regiments (Pengaruh Induksi Ketamin terhadap Ventilasi)

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We have studied the effect of ketamine induction on ventilation at three regiment premedications. Forty five patients (ASA 1) were allocated randomly into three experimental groups, comparable in age, height and weight, to receive one of the regiment premedication : a combination of 1 mg/kg.bw pethidine + 0.5 mg atropine; 2.5 mg Droperidol + 0.5 atropine or 1 mg/kg. bw pethidine + 2.5 mg Droperidol + 0.5 mg atropine. Ketamine 2 mg/kg.bw 2.5 mg Droperidol + 0.5 mg atropine as an induction agent was injected within one minute intravenously, 45 to 60 minutes after premedication. Variables measured : tidal volume, respiratory rate and PaCO2. The results were statistically analized using ANOVA or Kruskal Wallis one-way ANOVA. There was no significant changes in respiratory function after premedication. There was decreased tidal volume caused by Droperidol. The decrease of ventilation caused by ketamine induction was statistically significant (p less than 0.05). This was due to decrease of tidal volume by 25-30 percent, increase PaCO2 (5-8 torr) and secondary effect of decrease of PaO2 (17-26 torr). From this research therewas 20 percent cases with PaCO2 more than 45 torr and 20 percent cases PaO2 decreased to less than 60 torr. Ventilation after ketamine was not influenced by premedication used.

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Majalah Kedokteran Indonesia,45(3)1995:153-158

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: ., 1995

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ketamine

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