Leek (Allium fistulosum Linn) and Metabolism : 7. Prevention of the Depletion of -SH Containing Compounds in Rat Livers, in Toxicated by CCl4 (Bawang Prei (Allium fistulosum Linn.) dan Metabolisme : 7. Pencegahan Penurunan Kandungan Total Senyawa -SH dalam Hati Tikus Keracunan CCl4 oleh Sari Air Bawang Prei) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Leek (Allium fistulosum Linn) and Metabolism : 7. Prevention of the Depletion of -SH Containing Compounds in Rat Livers, in Toxicated by CCl4 (Bawang Prei (Allium fistulosum Linn.) dan Metabolisme : 7. Pencegahan Penurunan Kandungan Total Senyawa -SH dalam Hati Tikus Keracunan CCl4 oleh Sari Air Bawang Prei)

Harahap, Indriati Pramodo - Personal Name; Sadikin, Mohamad - Personal Name; Sunarti - Personal Name;

The ability of leek to prevent liver damage in rats intoxicated with CCl4 has been demonstrated histopathologically as well as based on enzymatic findings by observing GPT levels in serum. This study was performed to gain an understanding, at least partially, of the hepatoprotective mechanism of leek. A number of rats were divided radomly into three groups of seven animals. The first group, without treatment, served as the normal control group. The second groups was intoxicated only with a single dose of 0.55 mg CCl4/g body weight. The third groups received water extracts of leek, equivalent to 20 g leeks/kg body weight daily, for 8 days successively. At the end of the period, rats were intoxicated with an equal dose of CCl4. A standard diet was given to all of the rats. Forty eight hours after the administration of CCl4, the animals were killed. Determinations of GPT activity and the content of -SH group containing compounds were performed by examining the blood and liver homogenates, respectively. This study indicated that the content of -SH group containing compounds of the second groups of rats was significantly lower as compared to the other groups of rats, whereas the content of these compounds in the first and in the third group was practically identical. We suggested that CCl4 intoxication that leads to a decrease of -SH containing compound could be prevented by leek extract.

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Series Title: -
Call Number: Majalah Kedokteran Indonesia,45(2)1995:111-115
Publisher: : ., 1995
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Subject(s): plants, medicinal
plant extracts
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