Antibody Detection Against Pf155/RESA in a Hypoendemic Malaria Area, Wonosobo, Central Java (Deteksi Zat Anti terhadap Pf155/RESA pada Penduduk Daerah Hipoendemi Malaria di Wonosobo, Jawa Tengah) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Antibody Detection Against Pf155/RESA in a Hypoendemic Malaria Area, Wonosobo, Central Java (Deteksi Zat Anti terhadap Pf155/RESA pada Penduduk Daerah Hipoendemi Malaria di Wonosobo, Jawa Tengah)

Susanto, Lisawati - Personal Name; Muljono, Rusli - Personal Name; Astuty, Hendri - Personal Name;

A seroepidemiological study using a modified indirect fluorescence antibody test (MIFA) according to the IFA method described by Perlmann et al. had been conducted on 282 sera collected from people living in a malarious hypoendemic area in Wonosobo, Central Java. The aim of this study was to know the antibody response/antibody amount against Pf155/RESA of those people and its relationship whit age, splenomegaly and parasitemia. Results obtained showed that from 282 sera examined, 100 sera (35.5 percent) were positive. Of less than 15 years age group 25.9 percent were positive, whereas of more than 15 years age group 42.2percent were positive. The geometric mean reciprocal titre (GMRT) of population in this hypoendemic area was 2.46, whereas the geometric mean positive reciprocal titre (GMPRT) was 12.72. The GMRT of less than 15 years age group was 0.54 and of more than 15 years age group was 1.15. GMRT of the parasitemic group was 1.07 whereas of the aparasitemic group was 0.89. GMRT of the splenomegalic and nonsplenomegalic group were 0.69 and 0.91 respectively. It was shown by using the Chi-square test that there was a significant difference of antibody response, between less than 15 years old age group and more than 15 years old age group (p less than 0.05). It was concluded that in a hypoendemic area, where the infection rate is very low, infection might not play an important role in antibody formation (protective antibody). Further studies using larger samples and studies on sera from population of higher endemic areas (e.g. meso and hyperendemic) should be carried out to compare the results.

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Call Number: Majalah Kedokteran Indonesia,45(2)1995:84-88
Publisher: : ., 1995
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Subject(s): malaria
antibodies
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