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Vitamin A and Immunity : 2. Effect of Vitamin A on Serum Complement Activity (Vitamin A dan Imunitas : 2. Efek terhadap Aktivitas Komplemen Serum)

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Investigations showed that vitamin A deficiency clearly reduced host resistance against various infections. On the other hand, some infections like measles reduced serum vitamin A levels. In a previous study, we have demonstrated that vitamin A administration increased specific titers in rats serum, immunized against sheep red blood cells. In this paper, we report the influence of vitamin A administration on the serum complement activities in rats. A number of male rats, Wistar strain, were divided randomly into 3 groups of 6 rats. The first group received only a standard diet and served as a control group. The second group received vegetables oil utilized as a vitamin A solvent in the third group. The third group received 250 IU vitamin A/g body weight. Both the vegetable oil and the vitamin A were administered by intraperitoneal injection, for 5 consecutively days. In the sixth days, serum complement activities were assayed and the results were expressed in CH50 units. We found that vitamin A administration acould increase the serum complement activities. However, the increased was not significant statistically (p more than 0.05).

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Majalah Kedokteran Indonesia,45(1)1995:36-42

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: ., 1995

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vitamin a
immunity

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