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The Efficacy of Clarithromycin Therapy on Pneumonia (Efektivitas Pengobatan Clarithromycin pada Pneumonia yang di Dapat di Masyarakat)

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Clarithromycin is a new macrolide antibiotic which is active against Gram-positive and Gram negative bacteria. Community acquired pneumonia is mostly caused by Gram-positive bacilli. The effectiveness of twice daily 250 mg clarithomycin in the treatment of hospitalized patients with community acquired pneumonia was studied. This study is an open clinical trial without control. Subjects were 30 patients, 20 males and 10 females. There were 14 pneumonies, 12 bronkopneumonias and 4 pleuropneumonias. The effectiveness of treatment were 92.85 percent in pneumonia, 75 percent in pleuropneumonia and 100 percent in bronchopneumonia. No side effect was noted during treatment. The average length of treatment was 8.2 days. Most bacteria isolated from pretreatment sputum culture showed resistance to clarithromycin. After treatment resistant bacteria was still isolated from sputum cultures. Conclusions : clarithromycin is effective in the treatment of community acquired pneumonia. Microorganism that was isolated from sputum culture did not reflect the causative agents.

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Paru,15(1)1995:26-30

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: ., 1995

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antibiotics
pneumonia

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