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The Contribution of Alpha-1 Antitrypsin Deficiency as Chronicle Predisposition in Bronchitis Factor (Peranan Defisiensi Alfa-1 Antripsin sebagai Faktor Predisposisi Bronkitis Kronik)

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In the second phase of Indonesia's long term development, chronic bronchitis needs special attention since its social aspect will create problem in the community. Factors that influence the success of treatment, prevention and rehabilitation of chronic bronchitis are clear knowledge on risk factors of the disease. The environmental approach only to know the risk factors of chronic bronchitis is not enough since the individual factor (hereditary) has a big role (dutch hypothesis). The major risk factors of the chronic bronchitis are alpha-1 antitrypsin (AAT) deficiency, air population and smoking. The objective of this study was to determine the causal relationship between ATT deficiency and its interaction with chronic bronchitis. The study design was case-control. The results show that from 140 cases of chronic bronchitis and 245 controls with the male to female ratio of 2.4 to 1, the risk of getting chronic bronchitis due to ATT deficiency was 3.09. The risk of ATT deficiency with smoking in chronic bronchitis was 9.59. The risk of ATT deficiency with dust exposure in chronic bronchitis was 2.60. Analysis on the risk factors of chronic bronchitis could not be separated individually, but should be carried out as an interrelated unity. The environmental and clinical approach only are not enough to evaluate the magnitude of risk factors in chronic bronchitis, since the biomedical approach really has quite a big influence. The examination of ATT should also be done to ATT deficiency patient's family, since ATT deficiency is a hereditary condition. Thus, the preventive action could be done as early as possible, when the chronic bronchitis has not yet been manifested.

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Paru,15(1)1995:17-25

Publisher

: ., 1995

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bronchitis
alpha 1-antitrypsin

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