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Serological Evaluation of Polio Vaccination in Jambi (Evaluasi Serologis Vaksinasi Polio di Jambi)

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Study of evaluation of polio vaccination in the has been carried out in Jambi, in 1982. The objective of this study is to determine, (1) immune response to oral polio vaccine in the children immunized with a standard OPV I-II, (2) distribution of entero viruses, (3) antibody status of the children before immunizaton, and (4) cold chain of polio vaccines used in the field. Two hundred children of 2 to 36 months old were randomly sampled from the population in Kodya Jambi. One hundred children were immunized with OPV I-II, and 100 children were not immunized. Sera and rectal swabs were taken from the children, and examined by neutralization test and isolation test respectively test and isolation test respectively. The result shows that, before the children were immunized, 55 percent of those children had no anti-bodies at all to polio viruses. After vaccination, seroconversion rates to polio virus vaccine type 1, type 2, and type 3 were 86.6 percent, 83.9 percent, and 92 percent respectively. Potency test shows no reduction of the vaccine potencies after it's stored and used in the field. Prevalence of enteroviruses infections among the children, before vaccination, were 18.7 percent, and decreased to 6 percent after vaccination. It is concluded that, before vaccination, the of the children under 3 years of age were very low. Their to 2 doses of oral polio vaccine were very good. The distribution of enteroviruses in the study area were high before vaccination, and decreased sharply after vaccination. Cold chain of the vaccines, during the storage and after been used in the field, were good. It is suggested that children under 3 years of age in the study area should be vaccinated. Two doses of oral polio vaccine is sufficient for their basic immune response. Interference of Echo virus type 9 to the multiplication of polio virus vaccine in the intestinal tract and the development of in the children were discussed.

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Cermin Dunia Kedokteran,(100)1995:5-8

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: ., 1995

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poliomyelitis
vaccination

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