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The use of Antibiotics in Hospitalized Adult Typhoid Patients in an Indonesian Hospital
Typhoid fever was the third ranked disease among the top 10 diseases in hospitalized patients in Indonesia in 2011. There were increased drug resistance, increased number of carrier, and number of relapse cases. This study aimed to analyze the use of antibiotics in hospitalized adult typhoid patients in a hospital in Indonesia.
The data were extracted from medical records of drug use in adult typhoid patients hospitalized in the Indonesian Red Cross Hospital in Bogor (West Java) during the period of July to December 2012. The analysis for typhoid was qualitatively (DU90%) and quantitatively (DDD /hbd) using ATC/DDD method.
From 459 typhoid patients, the total use of antibiotics in hospitalized adult typhoid patients during the period of July to December 2012 was6.35 DDD/hbd. The use of ceftriaxone had the highest DDD/hbd which was equal to 4.10 DDD/hbd. This meant out of 100 typhoid patients, 4 patients received 2 g ceftriaxone per day. Ceftriaxone was given in injection form. Furthermore, there were more drugs in segment 10% than 90% segment. From 26 types of antibiotics, 7 were included in the DU 90% segment which were ceftriaxone (64.54%); levofloxacin (13.90%); ciprofloxacin (3.57%); meropenem (2.80%); metronidazole (2.52%); ampicillin-sulbactam (1.65%); cefditoren pivoxil (1.60%).
Ceftriaxone was the most widely used antibiotics in the treatment of hospitalized adult typhoid patients in a hospital in Indonesia.
Key words: antibiotics, typhoid, ATC/DDD, DU 90%
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