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Pengujian Stabilitas Sediaan Antiacne Berbahan Baku Aktif Nanopartikel Kitosan/Ekstrak Manggis – Pegagan

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Acne vulgaris is a common human skin disease and commonly was treatment by antiacne formula with antibiotics substances as active compounds. As alternative formula for treatment acne vulgaris and dicrease of antibiotics resistance effect, the new formula antiacne with chitosan/Garcinia mangostana-Centella asiatica extracts nanoparticles as active compound has been developed. For the evaluation of formula quality, the stability testing of antiacne formula with active substance chitosan/G. mangostana-C.asiatica extracts nanoparticles after storage
at room temperature for 24 weeks and 40oC/75% RH for 12 weeks have been examined. The stability testing was evaluated including therapeutical, physical, chemical and microbiologicaltests.

The therapeutical test of samples was observed by inhibition growth of Propionicbacterium acnes while the physical test was observed by organoleptic parameters such as stability of gel, color, odor, viscosity, and weight of samples. The chemical test was studied of pH and determination of marker compoundwhile the microbiologicaltest was evaluated the degree of contaminant bacteria and yeast.

The results of test showed that the antiacne formula have a good stability for all properties at two conditions of storage.

Keywords : Stability, antiacne, formula, chitosan, Garcinia mangostanaextract, Centella asiaticaextract

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Series Title

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Call Number

Buletin Penelitian Kesehatan, 41 (4) : 207-216

Publisher

Jakarta : Sekretariat Balitbangkes., 2013

Collation

10p

Language

ISBN/ISSN

0125-9695

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Edition

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Subject(s)

plants, medicinal

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