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Gambaran Kerusakan Mukosa Usus Mencit (Mus musculus) pada Infeksi Escherichia coli

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This study was aimed to determine whether the degree of E. coli infection can lead todigestive problems and severity according to the degree of infection. Tests were carried out in vivo in murine, experimental animals to see the severity of the intestinal mucosa by the degree of infection.

The study was conducted with only post test design with the negative control group design. At the first day of the treatment, group of mice were infected with a suspension of E.coli in volume of 0.1 ml, 0.2 ml, 0.3 ml, 0.4 ml, 0.5 m, 0.6 ml and 0.8 ml, while the control was given sterile distilled water per oral. At days 14 after treatment intestinal surgery and pathological examination were done. Intestinal was opened and cleaned then capture dusing Dinolite Microscope® which connected to the laptop.

Data were collected and analyzed using statistic program and tested using ANOVA to determine differences in the degree of infection and severity of the intestinal mucosa, in between infected and uninfected of mice.Condition of infected intestinal pathology showed severity depends on the concentration of a given infection. In the ANOVA analysis showed that there was a significant difference in the volume of a given infection. The more infections level, the poorer condition of the intestinal mucosa of mice. (P = 0,001)

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Series Title

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Call Number

Jurnal Vektor Penyakit, 8 (2) : 53-60

Publisher

Donggala : Balai Penelitian dan Pengembangan Pengendalian Penyakit Bersumber Binatang Donggala., 2014

Collation

8p

Language

ISBN/ISSN

1978-3647

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Edition

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Subject(s)

escherichia coli
MUCOUS MEMBRANE
INTESTINE

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