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Korelasi antara Ekspresi Protein Cyclooxygenase-2 (Cox-2) dengan Derajat Diferensiasi Karsinoma Sel Skuamosa Serviks Uteri

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The most common carcinoma of the uterine cervix is squamous cell carcinoma (75%). Numerous studies have emphasized the importance of cyclooxygenase-2 (COX-2) activity during carcinogenesis and overexpressed in any kind of malignancies.

The purpose of this study was to investigate the expression of protein COX-2 and its correlation with the differentiation grading in squamous cell carcinoma of the uterine cervix. The following samples were analyzed: 45 paraffin tissue blocks from patients with squamous cell carcinomas of the uterine cervix, including 15 samples of keratinizing squamous cell carcinomas, 15 samples of large cell non keratinizing squamous cell carcinomas and 15 samples of small cell non keratinizing squamous cell carcinomas. Immunohistochemical analysis was performed with a rabbit monoclonal antibody against human COX-2. Expression of protein COX-2 was positive in 37,8% of squamous cell carcinoma of the uterine cervix, but there was no a significant correlation between COX-2 with the differentiation grading (p = 0,422). Overexpression of protein COX-2 was found in both keratinizing squamous cell carcinoma and non keratinizing squamous cell carcinoma, but small cell non keratinizing squamous cell carcinomas showed infrequent and low expression.

These results suggested that increased COX-2 expression might play an important role as early phenomena in carcinogenesis of squamous cell carcinoma.

Keywords: Cyclooxygenase (COX-2); Differentiation grading; Squamous cell carcinoma

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Series Title

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Call Number

SEL: Jurnal Penelitian Kesehatan, 1(1) : 24-36

Publisher

Banda Aceh : Loka Litbang Biomedis Aceh., 2014

Collation

13p

Language

ISBN/ISSN

2356-2501

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Edition

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Subject(s)

carcinoma, squamous cell
PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES

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