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Efek Propolis Terhadap Fungsi dan Perlemakan Hati Tikus Putih (Rattus Norvegicus) Model Hiperkolesterolemia

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Cardiovascular disease has become the main cause of death due to hypercholesterolemia.
The aims of this research was to measure the effect of propolis on liver function and fatty liver of hypercholesterolemic Wistar rats.

This was an experimental study with pre-post design. Thirty male Wistar rats aged 12-16 week, weight 125-200 g were allocated into 6 groups. Group I: standard meal + aquadest-gavage; group II: standard meal + 0,054 gr propolis-gavage, group III: high cholesterol meal+PTU 0,01+aquadest gavage; group IV: high cholesterol meal+ Propiltiourasil (PTU) 0,01 + 0,054 gr propolis-gavage; group V: high cholesterol meal + PTU 0,01+ 0,108 gr propolis-gavage and group VI: high cholesterol meal + PTU 0,01+ 0,162 gr propolis-gavage. Serum glutamat-oksaloasetat transaminase (SGOT) and serum glutamate-piruvat transaminase (SGPT) levels before and after treatment were measure. Analisys of microscopic fatty liver was conducted after scarification of rats. Data were analysed by One Way Anova to LSD test.

The study showed that there were significant differences in SGOT and SGPT between groups. Fatty liver were highest in group I and lowest in group II. Provision of 0,054 g propolis improve liver function and decreased fatty liver of hypercholesterolemic rats.

Keywords : SGOT, SGPT, fatty liver, propolis

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Detail Information

Series Title

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Call Number

Penelitian Gizi dan Makanan, 37 (1) : 77-85

Publisher

Bogor : Puslitbang Gizi, Badan Litbang Kesehatan., 2014

Collation

9p

Language

ISBN/ISSN

0125-9717

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

rats
propolis
FATTY LIVER

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