Text

Deteksi Penanda Peningkatan Virulensi non Struktural Protein (NS1) Virus Avian Influenza H5N1 Asal Indonesia (Detection of Markers of Increased Virulence Non Structural Protein (NS I) Avian Influenza Virus H5N1 from Indonesia)

---

NS1 protein is a multifunction protein that plays key role of pathogenesis and virulence of avians influenza virus H5N1. The amino acid substitution at the position P42S, D92E, F103I, M106I and 5 amino acid deletion at the position 80 to 84 in NS1 protein reported increasing virulence of avians influenza virus H5N1. Several studies showed avians influenza virus H5N1 in Indonesia has dynamic changed.

This study aimed to analyze the markers of virulence of NS1 protein sequences of all H5N1 virus isolates from Indonesia. The source of NS1 protein sequence data gene obtained from GeneBank and Gisaid. Data were analyzed using Bioedit software.

The Results showed the isolates from Indonesia had substitutions P42S and 5 amino acids deletions at positions 80-84 resulting in the potential for increased virulence of the virus. However, amino acid substitution at the position D92E, F103L and M106I substitution were not found.

---

Availability

Detail Information

Series Title

-

Call Number

Vektora Jurnal Vektor dan Reservoir Penyakit, 6 (1

Publisher

Salatiga : Balai Besar Litbang Vektor dan Reservoir Penyakit., 2014

Collation

8p

Language

ISBN/ISSN

2085-868X

Classification

-

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

proteins
ORTHOMYXOVIRIDAE

Specific Detail Info

-

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment