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Bahan Aktif dalam Kombinasi Obat Flu dan Batuk-Pilek, dan Pemilihan Obat Flu yang Rasional
Flu or common-cold is an acute upper respiratory tract infection mainly caused by virus, and a self-limiting disease which is requires only symptomatic treatments to alleviate the symptoms. Common-cold medication is usually an OTC drug and a fixed-dose combination of various active ingredients. The purpose of this paper is to review the active ingredients in cold medicines and how to select the medicines rationally. This review is conducted cross-sectional with data sources derived from 56 references in the form of books, guidelines, on-line journals/articles or printed publications, using the keywords: common cold, cough, over-the-counter (OTC) drugs, non-prescription, self-medication, analgesics, sympathomimetics, antihistamines, decongestants, antibiotics, immunomodulators, food supplements, flu, and batuk pilek.
It is obtained about 191 fixed-dose combination of tablet and syrup which is indicated for reducing the symptoms of common-cold.
The main active ingredients of the fixed-dose combination are antihistamines and decongestants. An additional component is an analgesic, antitussive, expectorant and stimulant. The doses strength of each component is in accordance with the recommended dose, but noted there is still a dose preparation with decongestants (phenylpropanolamine) higher than recommended. No single cold preparations were able to overcome all the symptoms of flu at once, so the flu combination product becomes the primary of choice. When using a common-cold combination
product, it is important to select a product most suited to the individual and specific symptoms, as possibly not all the active ingredients are necessary for the patient.
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