Epidermal growth factor polymorphism most prevalent in stage II cervical carcinoma (Polimorfisme A61G pada gen EGF paling banyak pada karsinoina serviks stadium II) | Perpustakaan dan Galeri Kebijakan Kesehatan

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Epidermal growth factor polymorphism most prevalent in stage II cervical carcinoma (Polimorfisme A61G pada gen EGF paling banyak pada karsinoina serviks stadium II)

Kevin Dominique Tjandraprawira - Nama Orang; Edhyana Sahiratmadja - Nama Orang; Herman Susanto - Nama Orang; Rarndan Panigoro - Nama Orang; Yudi Mulyana Hidayat - Nama Orang;

ABSTRACT:

BACKGROUND
Cervical cancer ranks second among female cancers worldwide and is widely associated with human papilloma vtrus (HPV) infection. However, HPV infection progression is influenced by various host factors. Epidermal growth factor (EGF) is a host factor important for proper epithelial proliferation and development, and may play a role in cervical cancer progression. A functional A61G polymorphism in the EGF gene has been hypothesized to alter EGF concentration in vivo with increasing guanine content associated with greater EGF ll. However, a map ofA6I0 polymorphism distribution is not available for any population, including Indonesia. This study aims to determine the distribution of EGF A6IG polymorphism among cervical cancer patients at Dr. Hasan Sadikin General Hospital.

METHODS
A retrospective cross-sectional study was conducted between July-November 2010. Included were 61 cervical cancer patients of various stages at Dr. Hasan Sadikin hospital, who had previously undergone blood sample collection, DNA isolation and finally genotyping for EGF gene using Illumina BeadXpresse. Chi-square test was used to analyse the data.

RESULTS
The EGF A610 polymorphism was exhibited by 88.5% ofpatients (as genotypes AfG and GIG). The majority of patients with this polymorphism were of moderate severity (FIGO stage II and III, 42.6% and 38.1% respectively). Patients with the polymorphism but with the lightest severity (FIGO stage I) accounted for 22.2% of the population.

CONCLUSION
EGF A6 IG polymorphism affected the majority of cervical cancer patients and that once stratified, the patients showed intermediate severity in terms of their cancerous growth.

Keywords: Cervical cancer, EGF, A610 polymorphism

Ketersediaan

Belum memasukkan lokasi UNIVERSITAS MEDICINA, 33 (3) 2014 : 192-198

A0004491

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Judul Seri: -
No. Panggil: UNIVERSITAS MEDICINA, 33 (3) 2014 : 192-198
Penerbit: Jakarta : UNIVERSA MEDICINA/FK UNIVERSITAS TRISAKTI., 2014
Deskripsi Fisik: 7p
Bahasa
ISBN/ISSN: 1907-3062
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