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Quercetin reduce cardiomyocytes damage in type 2 diabetic rats (Kuersetin menurunkan kerusakan set otot jantung pada tikus diabetes melitus tipe 2)

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ABSTRACT
BACKGROUND
Diabetes mellitus (DM) is a group of metabolic diseases which are characterized by hyperglycemia, resulting in various complications. A major macrovascular complication of DM is cardiac failure due to cardiomyopathy. Hyperglycemia increases oxidative stress, so an oxidative-stress reducing therapeutic agent is required, e.g. the antioxidant quercetin. The aim of this study was to assess the effects of quercetin in reducing damage to cardiomyocytes of type 2 diabetic rats.

METHODS
This research is an experimental study using 40 rats. With simple random allocation, rats were divided into eight groups, then type 2 diabetes mellitus was induced using streptozotocin (5 rats per group). The test materia was quercetin given at doses of 5, 20 and 80 mg/kgBW/day orally for 4 weeks. Each single dose of quercetin was given in combination with glibenclamide 5 mg/ kgBW/day. After 4 weeks the rats were decapitated and the cardiac tissues taken to quantify the percentage of cell damage after hematoxylin-eosin staining (HE).

RESULTS
Quercetin at a dose of 80 mg/kg BW day can lower cardiomyocyte damage better than quercetin at doses of 5 or 20 mg/ BW/day. A combination of quercetin and glibenclamide can significantly lower levels of cardiomyocyte damage better than quercetin without glibenclamide (p

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UNIVERSITAS MEDICINA, 33 (3) 2014 : 185-191

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Jakarta : UNIVERSA MEDICINA/FK UNIVERSITAS TRISAKTI., 2014

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7p

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1907-3062

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