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Annona muricata leaves have strongest cytotoxic activity against breast cancer cells (Daun sirsak mempunyai aktifitas sitotoksik paling kuat terhadap kultur sel kanker payudara)

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ABSTRACT:

BACKGROUND
Plant-derived herbal compounds have a long history of clinical use, better patient tolerance and acceptance. The are freely available natural compounds that can be safely used to prevent various ailments. Plants have been the basis of traditional medicine throughout the world for thousands of years and are providing mankind with new remedies. The objective of this study was to determine the cytotoxicity of soursop (Anenn muricata Linn) leaves and pearl grass (Hedyotis caymbosa (L.) Lam.) on the hormone-dependent human breast carcinoma Michigan Cancer Foundation-7 (MCF-7) cell line.

METHODS
This study used two types of solvents (water and ethanol) in the extraction process and two incubation times (24 hours and 48 hours) in the MIT assays to analyze the cytotoxic effects of both plants.

RESU LTS
Preliminary results showed that the ethanolic extract of soursop leaves (SE) displayed cytotoxic effects against MCF-7 on 24- and 48-hour incubation times with ICso values of 88.788 pgiml and 14.678 1.1g/int, respectively. Ethanolic pearl grass extract (PE) showed similar results, with Ice values of 65.011 ugi ml on 24-hour incubation time and 52.329 agiml an 48-hour incubation time against MCF-7 cell line. However, the water extract of both plants displayed lower cytotoxic effect against MCF-7 cell line.

CONCLUSION
The ethanolic extract of both plants displayed cytotoxic effect against MCF-7. Soursop (Anona muricata Linn) leaves have the strongest cytotoxic activity against MCF-7 breast cancer cell line.

Keywords: Mieroculrure tetrazolium salt assay, Heco.aris corymbosa, Annona muricata, MCF-7

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UNIVERSITAS MEDICINA, 33 (3) 2014 : 179-184

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Jakarta : UNIVERSA MEDICINA/FK UNIVERSITAS TRISAKTI., 2014

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6p

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1907-3062

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