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Typhonium flagelliforme decreases protein expression in murine breast cancer (Typhonium flagelliforme menurunkan ekspresi protein pada kanker payudara mencit)

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ABSTRACT
An in vitro experimental research was conducted between October 2013 and January 2014. Neem lea were extracted in ethanol or hexane at various concentrations. A macrodilution test with 48-hour incubation time was done in triplicate on 8 groups of samples. These comprised the neem leaf ethanol extract (NLEE) at 0.5, 1.0, and 2.0 g/dL, neem leaf hexane extract (NLHE) at 0.5, 1.0, and 2.0 g/dL, positive control, and negative control groups. Fungal growth was detected on Sabouroud dextr
BACKGROUND

Aspergillus flavus is one of the causes of aspergillosis, with a high virulence and resistance to standard antifungals, resulting in a high mortality rate. Medicinal plants are increasingly used as they are relatively safer with minimal side effects. Previously we found that the ethanol extract of neem (tadirachia indica A Jus) leaves inhibits 4.flovits growth in vitro. However, most chemical compounds with antifungal effect are nonpolar. The purpose of this research was to compare the antifungal effect of neem leaves extracted in a nonpolar solvent to that of leaves extracted in a polar solvent.

METHODS
ose agar. Statistical analysis use Chi square and Fisher's exact test.

RESULTS
NLHE had a higher, but statistically non-significant, inhibitory effect on A. ems than NLEE (v0.996). At higher concentrations, the antifungal effect of NLHE is better than that of NLEE.

CONCLUSION
There is no significant difference in in-vitro inhibitory effectivity on A. Awns of neem leaves between extracts in polar and nonpolar solvents.

Keywords : Azadiracina indica, neem, A. Plus, ethanol, hexane. Antiftmeal

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

UNIVERSITAS MEDICINA, 33 (3) 2014 : 163-170

Penerbit

Jakarta : UNIVERSA MEDICINA/FK UNIVERSITAS TRISAKTI., 2014

Deskripsi Fisik

8p

Bahasa

ISBN/ISSN

1907-3062

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Tipe Media

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Tipe Pembawa

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Edisi

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