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The Effect o f Vitamin A (Retinal) Supplementationin i n hibiting The Decrease of Leydig Cells of Rats Exposed by Cigarette Smoke

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ABSTRACT.

Cigarette smoke is one of oxidants causing the increase offree radicals or reactive oxygen species generated through electron chain reaction. The extensive of reactive oxygen species triggers the lipid peroxide reaction in cells. Carotenoids are the secondary antioxidants obtained from foods. One of carotenoids is Vitamin A.

The aim of this research was to know the effect of vitamin A supplementation can inhibit the decrease of Leydig cells of rats exposed by cigarette smoke. This research was experimental research, using Randomized Post Test Only Control Group Design. The sample of this research was adult male rats of Balb-C strain. The rat samples were treated and observed for 35 days.

The result of research showed that the administration of 0,002 mg vitamin A showed no significant difference (p = 0.285) on the number of Leydig cells between control group and treated groups. Meanwhile, the administration of 0,004 mg vitamin A showed significant difference (p = 0.050) on the number of Leydig cells between control group and treated groups, where the number of leydig cells on treated groups was less than control group.

In conclusion, the administration of 0,002 mg and 0.004 mg vitamin A can not inhibit the decrease of the number of rat Leydig exposed by cigarette smoke. Therefore, it is suggested that it needs to be conducted the further research to know the impact of the vitamin A administration between the dosage of 0,002 mg and 0.004 mg.

Keywords : Vitamin A, cigarette smoke, sel Leydig.

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Jurnal Skala Husada 11 (2) 2014: 179-182

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Denpasar : Poltekes Denpasar., 2014

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4p

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1693-931x

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