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Evaluasi, Uji Stabilitas Fisik dan Sineresis Sediaan Gel yang Mengandung Minoksidil, Apigenin dan Perasan Herba Seledri (Apium graveolens L.)

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Minoxidil, apigenin and celery are believed to have the same bioactivity as a vasodilator that can widen blood vessels. This study discusses about the gel formulation in the scope of evaluation of gel preparation, using carbomer as a gelling agent each containing minoxidil, apigenin and celery juice.

The method used in gel evaluation were organoleptic observation, homogeneity, pH, consistency and viscosity; physical stability at 40±2 °C, 28±2 °C, 4±2 °C and syneresis. Based on the result, all gel formulations showed their consistency and viscosity were higher after 8 weeks of storage at room temperature. The rheogram of three gel formulations in term of flow properties remain unchanged after 8 weeks of storage. It was indicated that the flow properties of gel formulation was pseudoplastis tixotropic. The gel containing minoxidil, apigenin and celery juice showed good physical stability at 28±2 °C and 40±2 °C, but less stable at 4±2 °C after 14 weeks of storage. The highest number of syneresis was found in a gel containing celery juice.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Buletin Penelitian Kesehatan, 42 (4) : 213-222

Penerbit

Jakarta : Sekretariat Balitbangkes., 2014

Deskripsi Fisik

10p

Bahasa

ISBN/ISSN

0125-9695

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

plants, medicinal
APIGENIN

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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