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KoraIasi Kadar Vitamin D, dengan TNF-α dan Manifestasi Klinis pada Pasien Artritis Rematoid (Th e Correlation of Vitamin 0, TNF-α and Clinical Manifestation in Rheumatoid Arthritis Patients)

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ABSTRACT

Rheumatoid arthritis is an autoimmune disease which is initiated by T-cell dependent antigen activation that lead to nu immune response type. Tumor necrosis factor is the central cytokine in the AR pathogenesis. This research aimed to investigate the correlation between vitamin D, TNF-α and the clinical severity of rheumatoid arthritis. A cross sectional design was performed in 24 out-patients subject that meet diagnosis criteria based on ACR/EULAR 2010. The level of vitamin D and TNF-α were measured using ELISA method while the AR c linical manifestation was measured using DAS 28 score, VAS and functional scale.

Result shows vitamin 0 deficiency in 45,8% patients, and 66,6% with class I functional alteration. Vitamin D level have significant correlation with patients age (p=0,005, rr--0,553), length of sickness (p=0,009, r=-0,522), DAS (p=0,001, r=-0,615), number of joint involved, swallow joint (p=0,045, r=-0,413), VAS (p=0,006, r=-0,541), TNF-α level (p=0,048, r=-0,408) and patients functional status (p=0,039, r=-0,424). It can be concluded that vitamin D level have a significant correlation with TNF-α and clinical manifestation in rheumatoid arthritis.

Keywords: DAS 28, CRP, Rheumatoid Arthritis, TNF VAS, vitamin D.

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Jurnal Kedokteran Brawijaya 28 (3) 2014 : 30-34

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: Program Pascasarjana Universitas Airlangga., 2014

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5p

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