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Efek Waktu Paparan Genistein terhadap Pembentukan Jantung Embrio Zebrafish (The Effect of Genistein Exposure Time of Zebrafish Cardiac Formation)

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ABSTRACT

Genistein is o phytoestrogen that have been studied for their health benefits. The side effect of genisteinis not completely known. High dose of genistein exposure on the developmental stage could disturb fetal growth and increase mortality rate. The aim of thisstudy is to demonstrate the effect of different exposare times of genistein on zebrafish cardiac formation, by observing the heart rate and the thickness of embryo's pericardium. Zebrafish embryos were exposed to .10 MM genistein from 2, 24, and 48 hours post fertilization (hpf). The embryos were observed at 72 hpf using microscope with 40x objective iense, pericardium thickness were measured by micrometer on the lateral side of the embryos. The results of this study show that genistein exposure on early stage of zebrafish development could decrease the heart rate and cause pericardial oedema. These effect is decrease bydelaying the genistein exposure.

Keywords: Heart rate, percardial oedema, genistein, zebrafish

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Jurnal Kedokteran Brawijaya 28 (3) 2014 : 22-25

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: ., 2014

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4p

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