Peningkatan Ekspresi IFN-y pada Paru Mencit yang Diinduksi Protein Adhesin 38- kDa Mycobacterium tuberculosis dan ISCOM per Oral Increasing Expression of IFN-y Lung Mice Induced withMycobacteriumTuberculosisAdhesin38 Kda Protein and Oral ISCOM) | Perpustakaan dan Galeri Kebijakan Kesehatan

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Peningkatan Ekspresi IFN-y pada Paru Mencit yang Diinduksi Protein Adhesin 38- kDa Mycobacterium tuberculosis dan ISCOM per Oral Increasing Expression of IFN-y Lung Mice Induced withMycobacteriumTuberculosisAdhesin38 Kda Protein and Oral ISCOM)

M Fahrul Udin - Nama Orang; Wisnu Barlianto - Nama Orang; HMS Chandra Kusuma - Nama Orang;

ABSTRACT

Previous studies showed that tuberculosis vaccine induced a cellular immune response of 38-kDa M tuberculosis hemaggiutinin protein which was found in mice enterocytes. It can induce S-IgA secretion into the intestinal lumen and bronchiolus. It is known that the ISCOM is on effective adjuvantenhances the immune response. interferon(IFItexpression mainly occurs as a response to the microbes, like-viruses and bacteria, and their products.

This study aimed to investigate the impact of38-kDa adhesin protein administration with or without oral adjuvant ISCOM to the (IFN) expression in lung tissue of BALB/c mice. An experimental design was performed in 4 groups: control group, intervention group with 38-kDa protein adhesion administration, ISCOM adjuvant administration and combination of38-kilo protein adhesin with ISCOM. Expression of IFN-y was measured by immunohistochemical staining. Kruskall Wallis analysis identify significant difference of !FN-yexpression among all treatment groups (p=0,00). The Mann Whitney test stated that identify significant increasing of IFN-y expression in group with combination of protein adhesin and oral adjuvant ISCOM (mean±SD=126±17; p=0,000) when compared with the other groups. interestingly exposure with ISCOM only has potentiai effect in inducing iFN-y expression significantly whencompared to controls (p=0,000). It can be concluded that the administration of protein adhesin 38 kDa M tuberculosis will stimulate IFN-y expression in the lung tissue of BALSA mice, and the addition ofLSCOM will increase the impact.

Keywords: 38-kDa adhesin protein, interferon gamma, lung, Mycobacterium tuberculosis, oral vaccination

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Belum memasukkan lokasi Jurnal Kedokteran Brawijaya 28 (3) 2014 : 11-16

A0004366

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Judul Seri: -
No. Panggil: Jurnal Kedokteran Brawijaya 28 (3) 2014 : 11-16
Penerbit: Malang : Jurnal Kedokteran Brawijaya., 2014
Deskripsi Fisik: 6p
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