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Ekstrak Rosela Menurunkan Perlemakan dan Ekspresi ADMA Hepar akibat Diet Aterogenik pada Tikus (RoseHa's Extract Decrease Fatty Liver and ADMA Expression on Liver due to Atherogenic Diet in Mice) M Rasjad indra;

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ABSTRACT

Anthocyanin in rosella, as polyphenol antioxidant, has a potential impact to prevent the progressivity of disease related to oxidative stress. Atherogenic diet and oxidative stress will induce free radical attack on fat and protein compound resulting in fatty liver and increasing ADMA (asymmetric dimethylarginine) expression increase. This study aimed to investigate antioxidant effect of rosella’s extract in fatty liver and ADMA expression of Rat with atherogenic diet. Experimental study with post test only control group was conducted using four randomized experimental groups which were: positive control group (atherogenic diet), group 1 (rose/la's extract 150mekgitWiday + atherogenic diet), group 2 (roselia's extract 300mg/kgBW/day + atherogenic diet), and negative control group without intervention. Our findings revealed that rose/la's extract has potential impact in reducing fatty liver as expressed in significant reducing of fatty cells (p=0000). Based on immunohistochemistry examination, rosella extract consumption will decrease ADMA expression (p=0,000). It can be concluded that rose*, extract consumption at dosage 300mg/kgBW/day has significant impact in reducing fatty liver and ADMA expression due to atherogenic diet in Rat.

Keywords: ADMA expression on liver, atherogenicdiet, fatty liver, rosella

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No. Panggil

Jurnal Kedokteran Brawijaya 28 (3) 2014 : 6-10

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Mataram : Jurnal Kedokteran Brawijaya., 2014

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5p

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