Polifenol Buah Tin (Ficus corka Linn) Menghambat Peningkatan Kadar MCP-1 pada Tikus dengan Diet Tinggi Lemak (Polyphenols of Ficus carica Linn inhibit Elevation of MCP-1 Level of Mice with High Fat Diet); Retty Ratnanawati; -- Jurnal Kedokteran Brawijaya 28 (3) 2014 : 1-5 | Perpustakaan dan Galeri Kebijakan Kesehatan

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Polifenol Buah Tin (Ficus corka Linn) Menghambat Peningkatan Kadar MCP-1 pada Tikus dengan Diet Tinggi Lemak (Polyphenols of Ficus carica Linn inhibit Elevation of MCP-1 Level of Mice with High Fat Diet); Retty Ratnanawati; -- Jurnal Kedokteran Brawijaya 28 (3) 2014 : 1-5

Norma Lukitasari - Nama Orang; Diana Lyrawat - Nama Orang;

ABSTRACT

One of atherosclerosis pathogenesis was due to oxidativestress caused by an imbalance between oxidant and antioxidant. Tin fruit (Ficus carica Linn) contain polyphenol which functioned as antioxidant. This study aimed to determine whether palyphenol of tin fruit could prevent atherosclerosis through elevated serum of MCP-1 inhibition.

This research design was using post test only, which 25 male rats wistor strain devided into 5 groups and treated for 65 days. Group 1-5 respectively are negative control group (normal diet), positive control (high fat diet), A dose (high fat diet + tin fruit polyphenol 4,5mg/day), B dose (high fat diet +tin fruit polyphenol 9mg/day)and C dose (high fat diet +tin fruit polyphenoll8mg/day).

Result showed the increasing of MCP-1 serum level in positive control group as 1,21% compare to negative control one. Provision of 9mg/day tin fruit polyphenol lowered MCP-1 level serum as 0,88% compare to positive control gaup (p=0,000), meanwhile on the dose of 18mg/day could normalized the level of MCP-1serum. It can be concluded that polyp henol of tin fruit able to significantly inhibit the elevation of MCP-1 serum of male rat Wistar strain fed by high fat diet, with the maximum dose of 18 mg/day.

Keywords: Atherosclerosis, ficus carica, MCP-1 serum, polyphenols

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Belum memasukkan lokasi Jurnal Kedokteran Brawijaya 28 (3) 2014 : 1-5

A0004364

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Judul Seri: -
No. Panggil: Jurnal Kedokteran Brawijaya 28 (3) 2014 : 1-5
Penerbit: Mataram : Jurnal Kedokteran Brawijaya., 2014
Deskripsi Fisik: 5p
Bahasa
ISBN/ISSN: 2338-0772
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