Pengaruh Ekstrak Metanol Biji Mahoni terhadap Peningkatan Kadar Insulin, Penurunan Ekspresi TNF-α dan Perbaikan Jaringan Pankreas Tikus Diabetes (Effect of Methanolic Swetenia mahagoni Seed Extracts in Increasing insulin Level, Decreasing TNF-α Expression and Repairing Pancreatic Tissue Damage on Diabetic Rat); Tinny Endang H; Aulani’am | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Pengaruh Ekstrak Metanol Biji Mahoni terhadap Peningkatan Kadar Insulin, Penurunan Ekspresi TNF-α dan Perbaikan Jaringan Pankreas Tikus Diabetes (Effect of Methanolic Swetenia mahagoni Seed Extracts in Increasing insulin Level, Decreasing TNF-α Expression and Repairing Pancreatic Tissue Damage on Diabetic Rat); Tinny Endang H; Aulani’am

Nany Suryani - Personal Name; Tinny Endang H - Personal Name; Aulani’am - Personal Name;

ABSTRACT

Diabetes Mellitus (DM) is α disease with metabolism disorder signed by increasing of glucose blood (hyperglicemia), caused by disorder of insulin secretion and or increasing of insulin resistance. Therapy of Methanofic Swetenia mahagoni Seed Extracts is an alternative treatment forDM. The objective of this research is to prove the effect of extract of Swetenia mahagoni Jacq to increasing of insulin, decreasing Tumor Necrosis Factor (TNF-α) expression and repair pancreatic tissue damage of rat result Multiple Low Dose-Streptozotocin (MLD-S72)induced dose of 20 mg/kg weight for 5 doyssuccessively. Blood glucose of rat was measured using digital glucometer and categorized as DM if it is >300 mg/dl.

This research used 25 wistar strained white rat (Pettus norvegicus). Which were classified into 5 groups, they are one group of negative control, one group of positive control, and three groups of MLD-STZ induced given treatment of Methonolic Swetenia mahagoni Seed Extracts with dose of 100, 250 and 400 mg/kg weight for 7 days.

The result showed that treatment of Methanolic Swetenia mahagoni Seed Extracts with dose of 100, 250 and 400 mg/kg.BW decreased blood glucose 55,47%; 81,01% and 73,63% successively, increased insulin as 78,38%; 275,68% and 145,95%, decreased TNF-α expression as 30,34%; 67,28% don 49,92%, and improved damage of pancreos tissue from decreasing in the degree of insulitis (p

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Location name is not set Jurnal Kedokteran Brawijaya 27 (3) 2014 : 137-145

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Series Title: -
Call Number: Jurnal Kedokteran Brawijaya 27 (3) 2014 : 137-145
Publisher: Malang : Jurnal Kedokteran Brawijaya., 2013
Collation: 9p
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ISBN/ISSN: 2338-0772
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