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Efek Penambahan Ekstrak Echinacea pada Infeksi Plasmodium Berghei (The Effect of Extract Echinocea Supplementation on Plasmodium Berghei Infection)

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ABSTRACT

Immune responses against malaria can lead to immunopathologic condition. Echinacea purpurea is a potent agent to enhance immunity. This study aims to reveal the effect of Echinacea in the treatment of malaria in vivo. This study is pre and postest control group design using 24 mice mus musculus strain DDI male, aged 5 weeks, weight 20-25 gram divided into 5 groups: K- (no treatment); K+ (chloroquine); treatment 1 (0,65 mg Echinacea/mouse); treatment 2 (1,3 mg Echinoceemouse); treatment 3 (combination of chloroquine-echinaceo). Parasitemio was measured daily for 5days after 24 hours of infection and histological examination was performed on fifth day. ANOVA and Kruskal-Wallis used respectively to test the significance of differences in parasitemia and histological features.

The results show a significant difference of decreased parositemia (p=0,023) among groups. The parasitemia of echinacea group is inherently slow decline as a result of immune reaction, while on chloroquine is faster. There is increasing activities of a lien on the Echinacea group and no brain histological differences. it can be concluded that Echinacea reduced paracitemia decreasing and improve lien activity.

Keywords: Echinacea extract, histopothologic, malaria, parasitemia, Plasmodium berghei

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Jurnal Kedokteran Brawijaya 28 (3) 2014 : 146-155

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Malang : Jurnal Kedokteran Brawijaya., 2014

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10p

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0216-9347

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