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Hubungan antara Kadar Tumor Necrosis Factor-Alpha (TNF-α) Plasma dengan Kejang Demam Sederhana pada Anak (The Relationship between Levels of Tumor Necrosis Factor-Alpha (TNF-α) Plasma and Simple Febrile Seizures in Children); Masdar Muid, Sumarno Retoprawiro

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ABSTRACT

Febrile seizures are the most common cause of convulsions in children and frequently cause hospitalization on emergency basis. Preliminary studies in children suggest that the cytokine network is activated and may have a role in the pathogenesis of febrile seizures, but the precise clinical significance remains unclear. This study alms to establish a relationship between plasma levels of TNF-αand simple febrile seizures. Cross-sectional study was conductedfrom March to,4pril 2014 at Department of Pediatrics Saiful Anwar Hospital.

There were 38 samples that met the inclusion criteria; 19 patients of simple febrile seizures and 19 patients of febrile without seizures (ages 6 months to 5 years). Plasma levels of TNF-α were examined with ELISA. Independent t test analysis showed no significant differences in subject characteristics, rectal temperature and leukocyte levels. Mann-Whitney analysis showed no significant differences in subject characteristics of gender and CRP levels. Simple febrile seizures are more common in younger age than febrile without seizures.

Independent t test results also show that there ore significant differences between plasma levels of TNF-α simple febrile seizures group and febrile without seizures group (p=0,002). Spearman 's test results show there is a significant negative correlation between plasma levels of TNF-αgroup of simple febrile seizures and febrile without seizures group (r=-4533,12=0,001). It can be concluded that there is a relationship between plasma levels of TNF-αwith simple febrile seizures.

Keywords: Children, simple febrile seizures, TNF-a plasma

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Kedokteran Brawijaya 28 (2) 2014 : 115-119

Penerbit

Malang : Jurnal Kedokteran Brawijaya., 2014

Deskripsi Fisik

5p

Bahasa

ISBN/ISSN

0216-9347

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