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Ekstrak Ethanol Daun Sirsak (Annona Murkata) Berpotensi Memiliki Efek Kemoterapi pada Kanker Payudara Tikus Putih (Ethanol Extract of Soursop Leaves (Annona muricata) has Potential of Chemotherapy Effect onWhite Rats' Breast Cancer)

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ABSTRACT

Breast cancer is the most common cancer suffered in women and needs high cost chemotherapy which also has so many side effects. Leaves of the soursop (Annona muricata) contain acetogenin which is cytotoxic against the cancer cells. This study aims to determine the chemotherapy effects of soursop leaves to breast cancer of white rats.

This research was conducted in the experimental laboratory of anatomical pathology of medical faculty in Lampung University from May to September 2013 by using 25 female Sprague Dawley rats divided into 5 groups, namely group I as negative control, group II was given 75mg/kg DMBA, group III was given 75mg/kg DMBA + extract of soursop leaves 100mg,/kg, group Ill, 75mg/kg DMBA + extract of soursop leaves 200 mg/kg, 75mg/kg BB DMBA+ III 400mg/kg BW extract of soursop leaves. The soursop leave extracts were administered for 4 weeks. Histopathology examination was performed to assess apoptosis after administration of soursop leaves.

The results were analyzed using Kruskall Wallis test and Man Whitney test. Soursop leave ethanol extract can cause apoptosis in KIII, KIV, KV by 2,5%, 3,44%, and 3,56% higher thanthe apoptosis of positive control group by 1,80 % (p

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Kedokteran Brawijaya 28 (2) 2014 : 97-100

Penerbit

Malang : Jurnal Kedokteran Brawijaya., 2014

Deskripsi Fisik

4p

Bahasa

ISBN/ISSN

0216-9347

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