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Pengaruh Vitamin C dan Eterhadap Histologi Tuba Fallopii pada Tikus yang Dipapar MSG (The Effect of Vitamin C and E on the Fallopian Tubes Histology of MSG-exposed Rats)

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ABSTRACT

Monosodium glutamate (14SG) is sodium salt from glutamate acid used as flavor enhancer MSG affects tube motility on smooth muscle layers and the number offallopian tubesecretory epithelial cells. This research aims to determine the effect of vitamin C and combination on the number of secretor, epithelial cells and smooth muscle thickness of fallopian tubes in rats exposed to MSG for 42 days.

The research design is an experimental post-test control group design using 25 adult female rats divided into 5 groups, namely K His the negative control; K (+) MSG 0,7 mg/g 8W; PI received MSG 0,7 mg/g 8W +Vitamin C0,2mg/g+ Vitamin E0,04 Wig BW; HI received MSG 0,7mg/g 8W +vitamin C 0,4mg/g BW + vitamin E0,04 Wig SW; Pill received MSG 0,7mg/g BW + vitamin C 0,8mg/g SW + vitamin E 0,04111/g BW. On the 43'd day, the rats were terminated in pro estrus phase and their fallopian tube hystopathologies were examined with HE staining under Dot Slide microscope.

One way ANOVA test results show that the combination of vitamin C and E tend to increase the number of secretory epithelial cells and smooth muscle thickness (p=0,000 and p=0,042 respectively), presumably due to the decreasing of estrogen secretion on reproduction cycle. In short, the dosage combination of vitamin C and E tends to increase the amount of secretory epithelial cells and smooth muscle thickness fallopian tubes of MSG-exposed mice although significantly indistinctive.

Keywords: Fallopian

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Kedokteran Brawijaya 28 (2) 2014 : 63-67

Penerbit

Malang : Jurnal Kedokteran Brawijaya., 2014

Deskripsi Fisik

5p

Bahasa

ISBN/ISSN

0216-9347

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