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Pengaruh Suplementasi Seng terhadap CD 4+ Pengidap Human Immunodeficiency Virus

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Optimal immune response is needed to viral elimination, but in HIV infection the immune cell is the main target. Zinc has proved to increase immune response to various infection. However, its role in HIV infection has not understood.

This study aimed to analyze the effect of zinc supplementation to increase CD4+ in HIV-infected patients. This was an experimental study with pre test post test with control group design. Twenty HIV-infected persons were devided into 2 groups: control group which received Anti Retroviral Therapy (AZT) and the Zn+ART group received 5 mg zinc/d orally for one month and AZT. Field workers visited patients for checking compliance. Venous blood was taken from all of the subjects, the CD4+ cell count was measured and daily nutrient intake was analyzed. CD4+ cell count was determined by flowcytometri method. Daily food intake was determined by two 24 hour recall periods during 2 non consecutive days. Differential test between the two groups was performed using independent t-test or Mann Whitney test, when the distribution was not normal. Analysis of CD4+ differences before and after treatment in each group by paired t-test. The mean of CD4+ before zinc supplementation was 371.3 ± 126.8 cell/μL and increase to 415.2 ± 194.1 cell/μL after supplementation. However the increase 43.9 ± 83.5 cell/μL was not significantly different (p= 0.131). There was not a significant change CD4+ (p= 0.112) between both groups, possibly because the dose and duration of zinc supplementation.

Moreover, only one type of micronutrient given (zinc), also led to an increase CD4+ in our study did not significantly. Zinc supplementation in complement with AZT therapy was not significantly increase CD4+ in HIV patients.

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Series Title

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Call Number

Media Gizi Mikro, 5(1) 2013: 31-39

Publisher

Magelang : Puslitbang Ekologi Kesehatan,Badan Litbangkes., 2013

Collation

Media Gizi Mikro

Language

ISBN/ISSN

2086-5198

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Edition

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Subject(s)

zinc
HUMAN IMMUNODEFICIENCY VIRUS

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