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Resistensi Primer Mycobacterium Tuberculosis Dengan Target Gen Rpoβ

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ABSTRACT:

Detection of primary resistance in sputum samples of patients with pulmonary tuberculosis AFB (+) with molecular analysis on the target rpoB gene causes anti-tuberculosis drug resistance (OAT) rifarnpicin can be beneficial to the holder of a policy program to look for tuberculosis control efforts, one of attempt to overcome these problems is to deliver information about the resistance report in this interval.
This research observasional descriptive study, the research variables Mycobacterium tuberculosis rpoB gene mutations and patients with pulmonary TB sputum smear (+), with the number of 50 sputum samples with acidental sampling technique. This study results showed all the samples (50 samples) microscopic examination of smear and PCR diagnostics with primary genes and gene Tb1-Tb2 results are positive (+) tuberculosis (100%). By nested PCR amplification techniques to prove that the primary gene rpoB 1 negative results of 23 samples (46%), with the primary gene rpoB2 negative results in 13 samples (26%).

Conclusion: A total of 13 samples (26%) occurred mutation in the gene rpoB / is resistant to the antibiotic rifampin.
Kata Kunci: Primer resistance, Sputum, rpoB gene, Mycobacterium tuberculosis.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Kesehatan Prima, 8 (1) 2014: 1224-1231

Penerbit

Mataram : Jurnal Kesehatan Prima., 2014

Deskripsi Fisik

8p

Bahasa

ISBN/ISSN

1978-1334

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