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Validation of CURB-65 Scoring System in Indonesian Patients with HAP
ABSTRACT
Background: Hospital-acquired pneumonia (HAP) is a common infection occurring in hospitalized patients. CURBS 6$ (Confusion, Ummic, Respiratory, Blood Pressure, Age over 65) scoring system was developed to assess severity and risk in community-acquired pneumonia (CAP) but its use has not been validated In HAP patients in Indonesia. Objective: To validate the performance of CURB-65 scoring system to predict mortality in Indonesian patients with HAP
Methods: This iso validation study with retrospective cohort design. Data were taken from medical rem* in Cipto Mon,qunkusumo Hospital, Jakarta, Indonesia, from January 2006 to December 2012. Among 204 recruited HAP patients, 171 patients with complete data were included, Bosmer-Lemeshow test was conducted to test the accuracy and area under Receiver Operating Curve (ROC) was calculated to discriminate the performance of CURB-65 scoring system. The specific& yond sensitivity value of CURB-65 to predict mortality In HAP patients were analyzed. Statisticalanalysis was performed using SP55 16.0.
Results: The overall mortality proportion is 42.7%. Hosmentemeshow test shows good accuracy (pe1.00). The area under the ROC is 0.376, showing bad discriminating performance of CURB-65 scoring system. Using the cue-off value of score 2, the sensitivity of CURB-65 is 71.2% and its specificity is 42.996 to predict mortality in HAP
Conclusion: CURB-65 has low specificity and sensitivity value to predict mortality in HAP patients.
Key words: CURB-65, hospital-acquired pneumonia
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