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Paraneoplastic Limbic Encephalitis:Pendekatan Diagnosis dan Penatalaksanaan(Paraneoplastic Limbic Encephalitis: Diagnosis and Management Approaches)

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ABSTRACT

Paraneoplastic Limbic Encephalitis (PLE) is an entity belonging to Paraneoplastic Neurological Syndromes (PNS), associated with several tumors, caused by immune mediated disorders triggered by aberrant expression of onconeural antigens in the tumor. In the last few decades, 2 groups of antibodies associated with PLE have been identified, classical onconeural antibodies directed against the irmacellular antigens, and surface antigen antibodies. Each antibodygivescharacteristiccimical manifestations, magnetic resonance imaging (MRI)findings, and different response to therapy. Characteristic clinical manifestations are subacute or acute onset of recent memory loss, psychiatric manifestations, and seizures. Although the clinical spectrum has not yet been fully investigated, the clinical importance lies in their good response to immunotherapies. Generally, patients with surface antigen antibodies have more favorable prognosis because the clinical course tends to be less severe, and respond well with immunomodulation treatment.

Key words: paraneoplastic limbic encephalitis, diagnosis, management

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Cermin Dunia Kedokteran, 41 (1) 2014: 33-36

Penerbit

Jakarta : Kalbe Farma., 2014

Deskripsi Fisik

4p

Bahasa

ISBN/ISSN

0125-913x

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Tipe Media

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Tipe Pembawa

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