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Hipoksia Berpeluang Mencegah Kerusakan Sel BPankreas pada Pasien Diabetes Melitus Tipe 2:Tiniauan Biologi Molekular (Rote of Hypoxia in Preventing Pancreatic β-cell Damage in Type 2Diabetes Mellitus: Molecular Biology Review)

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ABSTRACT

Type 2 diabetes mellitus (DM) is a syndrome of impaired metabolism caused by reduced insulin secretion or decreased issue sensitivity to insulin. Type 2 DM begins with sustained hyperglycemia causing insulin resistance. Hyperglycemia also causes ROS (Reactive Oxygen Species) increase, especially in pancreatic β cells eventually lead, to cell damage and more severe type 2 DM. Hypoxia has been obsewed can increase cell glucose transporserthrough activation of transcription factor HIF-1α (hypoxia Inducible Factor 1α), reducing hyperglycemia and preventing destruction of pancreatic β cells in diabetic patients with insulin resistance. Hypoxia also lowers oxygen in cells as a source of ROS. ROS decrease will reduce risk of pancreatic β cells damage in Type 2 DM. Hypoxia likely prevents further damage in type 2 DM by preventing pancreatic β cells destruction.

Key words: type 2 diabetes melitus. hypox a, parcreatic β cells

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

CDK : Cermin Dunia Kedokteran, 41 (3) 2014: 198-20

Penerbit

Jakarta : Kalbe Farma., 2014

Deskripsi Fisik

4p

Bahasa

ISBN/ISSN

0125-913x

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

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Info Detail Spesifik

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Pernyataan Tanggungjawab

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