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Applicationof Pharmacogenomics on Drug Discovery and Development (AplikasiFarmakogenomik dalam Penemuan dan pengembangan Obat)

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ABSTRACT

Individual variations in the response to drugs and drug toxicity occur commonly in the clinical setting and in drug deveoprrent research protocols. Cumulative evidence strongly suggests that genetic polymorphisms in drug metabolizing enzymes, transporters, receptors and other drug targets are contributing to inter-individual differences in the efficacy and toxicity of drugs. Pharrnacogenomics refers to the application of genome-wide approaches in order to understand genetic influence on drug response and to develop novel drugs. This application pharnacogenomics has inplications in predicting a patient's response to medications, reducing adverse events and improving rationality of drug development. Pharmacogenomics profoundly change the way clinical drug trials are conducted, as well as influencing drug development process.This review provides an overview of the pharmacogenomics application on drug discovery and development.

Key words: Phamacogenomics. drug, discovery. development

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

CDK : Cermin Dunia Kedokteran, 41 (3) 2014: 181-18

Penerbit

: Kalbe Farma., 2014

Deskripsi Fisik

5p

Bahasa

ISBN/ISSN

0125-913x

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Tipe Pembawa

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Edisi

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