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Penetapan Kadar Artemisinin dalam Ekstrak Heksan Tanaman Artemisia annua L. Menggunakan Metode Densitometri

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Malaria desease is still problem health people in Indonesia, because morbiditas rate is high. Kinin and Klorokuin are used by most of people in the world, but it were resistance. Artemisinin and it’s derivate are used against resistance’s plasmodium. Artemisinin is isolation from Artemisia Annua L. plant. This is Chinese original plan but is cultivated in BPTO Tawangmangu. Artemisinin content determination in heksane extract from Artemisa annua using validated densitometry method. Artemisinin extract can be obtained by soxletasi using hexane and then fractionation was done by using acetonitril. This acetonitril extract is concentrated by rotary evaporator and artemisinin detection use thin layer chromatography with silica gel 60 GF 254 and eluen hexan :etil acetate (4:1). Separation was done by colloumm chromatography with silica gel and eluen hexane : etil acetate (4:1). Eluat which is content artemisinin determinated with the same way. Eluat with same Rf is fused and determination content using validated densitometry method. The validation result showed that linieritas with correlation coefficient is 0,9998, detection limit is 0,028 mg/ml, detection quantitation limit is 0,094 mg/ml, and deviation relative at least 2%. Recovery result artemisinin is 100,08%. Artemisinin content in heksane extract from Artemisia annua L with denisitometry method is 0,0850 grm and Artemisinin content in Artemisia annua L plant is 0,02%

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Media Litbang Kesehatan, 23(1): 15-22

Penerbit

Jakarta : Sekretariat Badan Litbang Kesehatan., 2013

Deskripsi Fisik

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Bahasa

ISBN/ISSN

0853-9987

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

plant extracts
ARTEMISININ

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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