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Hubungan Kadar Tiroglobulin, Tsh dan Ft4 Serum pada Anak Usia Sekolah di Tiga Kabupaten dengan Tingkat Endemisitas Defisiensi-Iodium Berbeda (Association Between the Serum Thyroglobulin, Tsh, and Ft4 among School-Aged Children in Three Districts with DIF

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Iodine deficiency lowers circulating thyroxine (T4) and raises serum Thyroid Stimulating Hormone (TSH), where free T4 (fT4) and TSH have strong corelation with thyroglobulin (Tg). The results from population studies indicate, Tg appears to be a valuable indicator of thyroid status, but it has yet to be fully explored. This study aimed to measure the association between serum Tg with TSH and fT4 as alternatif indicators thyroid status in school-aged children. This was a cross-sectional study of sample of 398 schoolchildren aged 10-12 years in three districts with different iodine-deficiency endemicity level, i.e. Pati as a mild endemic district, Purbalingga as a moderate endemic district, and Malang as a severe endemic district. Children’s blood have taken 3 cc as a sample for the determination of Tg, TSH, and fT4. Enzyme-Linked Immunosorbent Assay (ELISA) was used to determine Tg, TSH and fT4. Mean of serum Tg 14.3 ± 11.1 ng/mL (cut-off 2-50 ng/mL), TSH 3.7 ± 2.2 µIU/mL (cut-off 0.3-6.2), fT4 1.4 ± 0.4 ng/dL (cut-off 0.8-2.0 ng/dL). Correlation analysis was showed the significance of Tg and TSH (p< 0.05) and Tg with fT4 (p< 0.05). The significance analysis of Tg with TSH and fT4 may be evaluated as indicator for thyroid function in school-aged children in iodine-deficiency endemic areas.

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Series Title

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Call Number

Penelitian Gizi dan Makanan, 36(1):12-19

Publisher

Bogor : Puslitbang Gizi, Badan Litbang Kesehatan., 2013

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ISBN/ISSN

0125-9717

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Edition

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Subject(s)

thyrotropin
iodine
THYROGLOBULIN

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