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Manajemen Anestetik Sindrom Antifosfolipid dengan Komplikasi Sindrom HELLP ( Anesthetic Management of Antiphospholipid Syndrome Complicated with HELLP Syndrome)

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ABSTRACT

Antiphospholipid syndrome (APS) is defined as an autoimmune disorder characterized by recurrent thrombosis or obstetrical morbidity. One of obstetric complications in patients with APS is HELLP syndrome (occurring in 0.01 to 0.2% of pregnancies). One to 5% of healthy individuals have antiphospholipid antibodies (aPL). Clinical manifestations of APS are recurrent venous or arterial thrombosis and/or fetal loss. Some theories of pathogenesis of thrombosis in APS patients include decreased plasminogen activity, increased platelet aggregation, inhibition of prostacyclin and protein C, and increased factor VIII. Anesthetic management of APS includes techniques of regional anesthesia when normal coagulation function persist, or general anesthesia with a combination of fentanyl and ketamine in PCA if coagulation function drops below normal, and administration of standard thronnboprophylaxis. Further complications of APS should be prevented by use of heparin and steroids.

Key words: antiphosphotipid syndrome, HELLP syndrome, manifestations, pathogenesis, anesthetic management

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Ketersediaan

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Judul Seri

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No. Panggil

CDK:Cermin Dunia Kedokteran, 40 (7) 2013: 3p.

Penerbit

Jakarta : Kalbe Farma., 2013

Deskripsi Fisik

3p

Bahasa

ISBN/ISSN

0125-913x

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