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Scurrula atropurpurea increases nitric oxide and decreases malondialdehyde in hypertensive rats (Benalu teh meningkatkan kadar nitrit oksida dan menurunkan kadar malondialdehid pada tikus hipertensi

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BACKGROUND
Hypertension is the mosi prevalent chronic disease and has an impact on Olle billion people. Production of superoxide radicals and endothelial dysfunction are involved in hyperrension. Scurrula atropurpureu (BL.) Dans. is a tea plant parasite. This study aimed to evaluate the role of Scurrula atropurpureu (BL.) Dans. on nitric oxide (NO) as a marker of endotheJiaJ dysfunction and malondialdehyde (MDA) as a marker of oxidative stress in hypertensivc rats.

METHOOS
Th is study subjected rats to deoxycorticosternne acetate (DOCA)-induced hypertension, The experimental groups consisting of the control group and 3 hypertension groups receiving Scurulla atropurpurea extract at a dosage of 50;1OO; and 200 mg/KgBW. Scavenging activity of Scurulla atropurpurea (BL.) extract was analyzed by the 1.1diphenyl-2-picrylhydrazyl (DPPH) method. The levels of arterial nitric oxide (NO) and pulmonary malondialdehyde (MDA) were analyzed by spectrophotometry, ANOVA and a post hoc test were applied to find the difference of arterial NO and pulmonary MDA levels herween groups.

RESULTS
The level of arterial NO was significantly decrcased in the hypcrtension groups as cornpared with the control group, while the level of pulrnonary MDA was significanly incrcased (p

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

UNIVERSA MEDICINA, 32 (1) 2013: 44-50

Penerbit

Jakarta : Puslitbang Farmasi, Badan Litbang Kesehatan., 2013

Deskripsi Fisik

7p

Bahasa

ISBN/ISSN

1907-3062

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

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