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Extract of mangosteen increases high density lipoprotein levels in rats fed high lipid (Ekstrak Kulit Buah Manggis meningkatkan kadar high density lipoprotein pada tikus diet tinggi lemak

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BACKGROUND
ln cardiovascular medicine, Garcinia m angostana has been used as an antioxidant to inhibit oxidation oflow density Iipoproteins and as an antiobesity agent. The effect of Garcinia mangostana on hyperlipidemia is unknown. The aim of this study was to evaluate the effect of an ethanolic extract of Garcinia mungostana pericarp on lipid profile in rats fed a high lipid diet.

METHODS
A total of 40 rats were divided into five groups control. high lipid diet, and high lipid diet + ethanolic extract of Garcinia mangostana pericarp at dosages of 200, 400, and 800 mglkg body weight. The control group received a standard diet for 60 days. The high lipid diet group received standard diet plus egg yolk, goat fat, cholic acid, and pig fat for 60 days with or without ethanolic extract ofGarcinia mangostana pericarp by the oral route. After 60 days, rats were anesthesized with ether for collection of blood by cardiac puncture. Analysis of blood lipid profile comprised colorimetric determination of cholesterol, triglyceride, low density lipoprotein (LDL), and high density lipoprotein (HDL).

RESULTS
From the results of one-way ANOVA it was concluded that there were significant bctween-group differences in cholesterol, trygliceride, LDL, and HDL levels (p=0.000). Ethanolic extract of Garcinia mangostana pericarp significantly decreased cholesterol, trygliceride, and LDL levels, starting at 400 mg/kg body weight (p=0.000). Ethanolic extract of Garcinia mangostana pericarp significantly increased HDL level starting at 200 mg/kg body weight (p=0.000).

CONCLUSION
Ethanolic extract of Garcinia mungostana pericarp has a beneficial effect on
I ipid profile in rats on a high lipid diet.

Key wor ds: Mangosteen. lipid profile, high lipid diet, rats

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

UNIVERSA MEDICINA, 32 (1) 2013: 37-43

Penerbit

Jakarta : Puslitbang Farmasi, Badan Litbang Kesehatan., 2013

Deskripsi Fisik

7p

Bahasa

ISBN/ISSN

1907-3062

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Tipe Media

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