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Levels of Thyroid Peroxidase Antibodies is Higher in Threatened Abortion (Kadar Tiroid Peroksidase Antibodi lebih Tinggi pada Abortus Iminens)

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Objective: To assess the relationship between the incidence of threatened abortion with serum levels of TPO antibodies.

Methods: This was cross-sectional study involving subjects 40 cases and 40 controls. The study was conducted September 2012 to No¬vember 2012. The difference in the levels of thyroid peroxidase an¬tibody was tested by Mann-Whitney test.

Result: In this study, hypothyroidism was found only in the abortion group, as many as 6 subjects (15%) and subclinical hypothyroidism was more prevalent in threatened abortion group, found in 2 people (5%), compared to normal pregnant group, found in only 1 person (2.5%). This study revealed a significant difference in the mean le¬vels of TPO antibodies in the threatened abortion and normal preg¬nancy group. The mean levels of TPO antibodies in threatened abor¬tion group was 91.76 ± 133.18 IU/ml with the lowest level of 14.41 IU/m1 and the highest levels of 534.47 IU/m1 while in the normal pregnancy group found an average 12.97 ± 3.91 IU/ml with the lo¬west value 2.02 IU/ml and the highest value of 20.78 IU/ml. In this study, subjects with TPO antibody levels L 125 IU/ml, all of them ex¬perienced threatened abortion (n = 7) and found the risk of miscar¬riage by 2.212-fold compared with subjects with TPO levels < 125 IU/ml.

Conclusion: There are differences in the levels of TPO antibodies in patients with threatened abortion and in normal pregnancies, with average levels of TPO antibodies in imminent abortion group is higher than normal pregnancy group. There is a relationship bet¬ween TPO antibody levels L. 125 IU/m1 with the incidence of threat-ened abortion, with the risk of threatened abortion increasing 2.212 times. [Indones J Obstet Gynecol 2013; 1-3: 134-8]

Keywords: threatened abortion, thyroid peroxidase antibody (TPO)

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Indonesian Journal of Obstetrict and Gynecology, 1

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Jakarta : Indonesian Society of Obstetetrict and Gynecology., 2013

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5p

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2338-6401

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