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The Estrogen Receptor Concentration and Co13A1 Gene Immunoexpressio in Uterosacral Ligament is Correlated with Postmenopausal Uterine Prolapse (Konsentrasi Reseptor Estrogen dengan Imunoekspresi Gen Col3A1 pada Ligamentum Sakrouterinum Berkorelasi dengan Kejadian Prolaps Uteri Pascamenopause)

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Abstract
Objective: To analyze correlation between concentration of estro¬gen receptor and imunoexpression of Co13A1 gene on uterosacral ligament of postmenopausal uterine prolapse patient.

Methods: This is a cross-sectional analytic observational study in¬volving 32 subjects who met inclusion criteria. Samples are taken consecutively in Dr. Hasan Sadikin Hospital in January 1st - Decem¬ber 31st 2012. Statistical analysis was performed with non-paramet¬ric Mann-Whitney test and Spearman's rho non-parametric correla¬tion test.

Result: There is no significant difference of estrogen receptor con¬centration between postmenopausal women with and without uter¬ine prolapse (p = 0.377), while there is no significant difference of Col3A1 gene immunoexpression between postmenopausal women with and without uterine prolapse (p = 0.119) either. There is a sig¬nificant positive correlation between the estrogen receptor concen¬tration and Col3A1 gene immunoexpression in uterosacral ligament of postmenopausal uterine prolapse patients (p = 0.002, r= 0.711).

Conclusion: There is a positive correlation between the estrogen re¬ceptor concentration and Co13A1 gene immunoexpression in ute¬rosacral ligament of postmenopausal uterine prolapse patients.
[Indones J Obstet Gynecol 2013; 37-2: 103-6]

Keywords: Co13A1 gene, estrogen receptor, menopause, uterine prolapse, uterosacral ligament

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Judul Seri

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No. Panggil

Indonesian Journal of Obstetrict and Gynecology, 3

Penerbit

Jakarta : Indonesian Society of Obstetetrict and Gynecology., 2013

Deskripsi Fisik

4p

Bahasa

ISBN/ISSN

2338-6401

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Tipe Media

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Tipe Pembawa

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Pernyataan Tanggungjawab

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