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Betamethasone was more Effective than N-acetylcysteine for Lung Maturation ( Betametason lebih Efektif dibandingkan N-acetylcystein untuk Pematangan Paru)

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Abstract
Objective: To compare the effectivity of N-acetylcysteine with Be¬tamethasone in fetal lung maturation.

Methods: This research was a double blind randomized clinical tri¬als in women threatened by preterm delivery (28 to 34 weeks of gestation).

Results: There were 90 subjects randomly assigned to N-acetylcys¬teine group (n=30), betamethasone group (n=30), and the control group (who had not been given a tocolytic, n=30). Fetal lung matu¬ration was assessed with the p. The values for lung maturation at random were 5 foams. After being tested with the Tapp, there were significant differences between the 3 groups of this study based on analysis of variance (ANOVA) (p = 0.001). The average foam on the N-acetylcysteine was 4.8 ± 1.3 while in the group Betamethasone, was 3.2 ± 1.0, and the average amount of foam in the control group was 5.5 ± 1.6. The end point of the Tapp were mature and immature, which in the N-acetylcysteine group there were 21 subjects (70.0%) with mature lung, Betamethasone groups 28 subjects (93.3%) with mature lungs, whereas in the control group, there were 15 subjects (50.0%) with mature lung.

Conclusion: Betamethasone was more effective than N-acetylcyste¬ine for lung maturation in women threatened with preterm delivery. [Indones J Obstet Gynecol 2013; 37-1: 21-5]

Keywords: betamethasone, fetal lung maturation, N-acetylcysteine

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Indonesian Journal of Obstetrict and Gynecology, 3

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Jakarta : Indonesian Society of Obstetetrict and Gynecology., 2013

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5p

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2338-6401

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