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Typhoid Fever as a Triggering Factor in Acute and Intractable Bronchial Asthma Attack

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Typhoid fever is an enteric infection caused by Salmonella typhi. In Indonesia, typhoid fever is endemic with high incidence of the disease. In daily practice we frequently have patients with bronchial asthma, and it is becoming worse when these patients get typhoid fever After oral ingestion, Salmonella typhi invades the the intestine mucosa after conducted by microbial binding to epithelial cells, destroying the microfold cells (M cell) then passed through the lamina propria and detected by dendritic cells (DC) which express a variety ofpathogen recognition receptors on the surfaces, including Toll-Like Receptor (TLR). expressed on macrophages and on intestinal epithelial cells inducing degradation of IxBa, and translocation of NF-KB (Nuclear Factor-Kappa Beta). This process initiates the induction of pro-inflammatory gene expression profile adhesion molecules, chemokines, adhesion molecules, and other proteins that induce and perpetuate the inflammation in host cells then will induce acute ant intractable attack of bronchial asthma. The role oftyphoid fever in bronchial asthma, especially in persons with acute attack of b312 I Acta Medica Indonesiana - The Indonesian Journal of Internal Medicine ronchial asthma, is not well understood. In this article, we will discuss the role of iyphoid fever in the bronchial asthma patients which may cause bronchial asthma significantly become more severe even triggering the acute and intractable attack of bronchial asthma. This fact makes an important point, to treat completely the typh6id fever in patients with bronchial asthma.
Key words: typhoid fever, Salmonella typhi, bronchial asthma, acute and intractable attack

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Series Title

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Call Number

acta Medica Indonesiana, 45 (4) 2012 : 312-320

Publisher

Jakarta : FKUI., 2013

Collation

9p

Language

ISBN/ISSN

0125-9326

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Edition

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Subject(s)

asthma
TYHOID FEVER
LAURENTIUS A PRMAMONO

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