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Correlation Between T2* Cardiovascular Magnetic Resonance with Left Ventricular Function and Mass in Adolescent and Adult Major Thalassemia Patients with Iron Overload

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Aim: to assess for a correlation between T2 *CMR with LV function and mass in thalassemic patients with iron overload. Methods: a cross-sectional study on thalassemic patients was conducted between July and September 2010 at Cipto Mangunkusumo and Premier Hospitals, Jakarta, Indonesia. Clinical examinations, review of medical charts, electrocardiography, echocardiography, and T2 *CMR were performed. Cardiac siderosis was measured by T2 *CMR conduction time. Left ventricle diastolic and systolic functions, as well as LV mass index were measured using echocardiography. Correlations between T2 *CMR and echocardiographyfindings, as well as serum ferritin were determined using Pearson 's and Spearman 's tests. Results: thirty patients aged 13-41 years were enrolled, of whom two-thirds had fi-thalassemia major and one-third had HbE/β-thalassemia. Diastolic dysfungsion was identified in 8 patients, whereas sytolic fungtion was normal in all patiens. Increased LV mass index was found in 3 patiens. T2*CMR conduction times ranged from 8.98 to 55.04 ms and a value below 20 ms was demonstrated in 14 patients. There was a statistically significant moderate positive correlation of T2*CMR Conduction Time With E/A ratio (r = 0.471, P=0.009), but no correlation was found with LV mass index (r=0.097, P=0.608) a Moderate Negative correlation was faund between T2*CMR And Serum Ferritin (r=-0.514, P=0.004), while a moderate negative correlation was faund between serum ferritin and E/A ratio (r= -0.425, P= 0.019). Conclusion: T2*CMR myocardial conduction time has a moderate positive correlation with diastolic function, moderate negative correlation with serum ferritin, but not with LV mass index and sytolic function.

Key word: T2* cardiovascular magnetic resonance, diastolic dysfungtion, iron overload, thalassemia major

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Series Title

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Call Number

acta Medica Indonesiana, 45 (4) 2012 : 295-301

Publisher

Jakarta : Puslitbang Farmasi, Badan Litbang Kesehatan., 2013

Collation

7p

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ISBN/ISSN

0125-9326

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Subject(s)

thalassemia
iron

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